JRF for antimalarial drug Discovery Project on “Discovering Antimalarials
from Marine Organisms (phase III): Bulk Recollection of Promising Marine
Organisms-Isolation, Purification, Characterization and Chemical Synthesis
of Marine derived Antimalarials”
This multi institutional DBT project will use state of the art activity guided HPLC
purification of antiplasmodial molecules derived from extracts of marine organisms.
Screening of extracts and purified molecules will be done in microtiter plate format by
ex vivo culture of Plasmodium falciparum strains in human red blood cells and inhibition
of growth of malaria parasite will be monitored by SYBR Green based Fluorescence
screen. Selectivity Indices will be determined by comparing IC50 (Mammalian cell)/IC50
(P.falciparum). Only those with good credentials in chromatography, Spectroscopy,
Molecular Biology, Cell biology, diligent habits of experiment documentation and
aptitude for drug discovery need apply within six weeks to:
Dr Dinkar Sahal,
Malaria Research Laboratory,
International Centre for Genetic Engineering and Biotechnology,
New Delhi 110 067.
dinkar@icgeb.res.in
Notification date :13th August 2012
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